Can Tylenol (acetaminophen) deplete glutathione levels in the body? A Possible Antidote for Tylenol (Paracetamol) Overdose American Council on Science and Health Tylenol's Impact on Glutathione and Liver Damage Influencers keep telling you that paracetamol (Tylenol acetaminophen) drains your glutathione levels and that taking it eats up your antioxidants. But the science doesnt back that claim. Funny TYLENOL [Acetaminophen] metabolism A lot of GLUTATHIONE is needed to deal with the Oxidative Stress generated by the CYP 450 metabolism of Tylenol. When people go to the ER for Tylenol Overdose What To Avoid When Taking Glutathione