Too much paracetamol = dangerous because of how your liver processes it. *Normal dose:* About 90 95% gets broken down safely by glucuronidation + sulfation non toxic stuff you pee out. *The problem Skin whitening Glutathione Before Taking Glutathione for Skin Whitening Skin whitening Glutathione tablets injections Tylenol, Autism, And The Glutathione Connection OC Integrative Medicine g glutamyl cycle. Depletion of glutathione by acetaminophen leads to Download Scientific Diagram Acetaminophen from liver to brain: New insights into drug pharmacological action and toxicity ScienceDirect Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.