Early life acetaminophen exposure, glutathione S transferase genes, and development of adolescent asthma in a high risk birth cohort Journal of Allergy and Clinical Immunology Tylenol Liver Damage Signs, Causes, Dosage, Stages & Prognosis Tylenol's Impact on Glutathione and Liver Damage The Hidden Impact of Acetaminophen Well Rooted Glutathione Benefits for Better Thyroid Health Paloma Health Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.