NRF2 Rewires Cellular Metabolism to Support the Antioxidant Response IntechOpen Glutathione synthesis in the mouse liver supports lipid abundance through NRF2 repression Nature Communications Sulforaphane boosts our natural cellular defenses. It does this by activating Nrf2, our body's primary detoxification, anti inflammatory, and antioxidant pathway. Nrf2 turns on phase 2 detoxification enzymes, helping us deal with daily Enhanced B Raf mediated NRF2 gene transcription and HATs mediated NRF2 protein acetylation contributes to ABCC1 mediated chemoresistance and glutathione mediated survival in acquired topoisomerase II poison resistant cancer cells ScienceDirect NRF2 is part of a group of transcription factors called nuclear receptors The role of Nrf1 and Nrf2 in the regulation of glutathione and redox dynamics in the developing zebrafish embryo ScienceDirect