Acetaminophen Pathway (toxic doses), Pharmacokinetics Is Tylenol Safe During Pregnancy? Understanding Risk Factors Seeking Health Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Here's how to make Tylenol work way better Dose it correctly: 1,000 mg at a time, spaced every 8 hours. Smaller doses don't control pain as well. Take it Taking Glutathione Supplement? Here's What To Avoid Cellular Prime Figure 1: CMAJ