Functional neurologist discusses Tylenol use after President Trump's big announcement linking Tylenol to autism Acetaminophen (Paracetamol) Metabolites Induce Vasodilation and Hypotension by Activating Kv7 Potassium Channels Directly and Indirectly Arteriosclerosis, Thrombosis, and Vascular Biology Glutathione Sepharose High Performance GST tagged protein purification resin Cytiva Agarose Resin Market Size & Share Outlook to 2030 Efficacy of Oral N Acetylcysteine in the Treatment of Acetaminophen Overdose New England Journal of Medicine Yes there is good evidence that acetaminophen (the active ingredient in Tylenol) can deplete glutathione under certain conditions. But whether that matters depends on dose, duration, and individual factors.