Tylenol Avoid or Not to Avoid? Acetaminophen (Tylenol) can deplete glutathione, your body's most important detox antioxidant. This matters even more if your child has an MTHFR gene mutation, which Tylenol's Impact on Glutathione and Liver Damage Myth busting, Acetaminophen version. "Avoid Acetaminophen (Tylenol) because it causes glutathione depletion". Truth?? As a pediatrician and ER doctor and as moms we're often asked about this. And we understand why: Tylenol's Impact on Glutathione and Liver Damage Sex differences in glutathione metabolism and acetaminophen toxicity How to Fix Glutathione from Tyleon TikTok